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Model showing the early consequences of RT and mechanisms of persistent decrease in salivary secretion. Adenosine diphosphate ribose (ADPR) is the intracellular ligand that binds to and gates. TRPM2: transient receptor potential melastatin 2. MCU: mitochondrial Ca2+ uniporter. SOCE: Store-operated Ca2+ entry. STIM1: stromal interaction molecule 1, IR: irradiation. ROS: reactive oxygen species [55].
