Table 1.
Bempedoic acid monotherapy dose–response model
| Parameter | Estimate | SE | 95% CI |
|---|---|---|---|
| Baseline LDL-C, mg/dL | 147.1 | 1.1 | (144.9, 149.3) |
| k out, h–1 | 0.01 | FIX | — |
| E max-BA | −0.34 | 0.01 | (−0.36, −0.32) |
| ED50-BA, mg | 44.0 | 3.8 | (36.6, 51.3) |
| HillBA | 1 (FIX) | — | — |
| Residual error | |||
| Proportional, % | 8.4 | — | (7.5, 9.3) |
| Additive, mg/dL | 11.4 | 0.6 | (10.3, 12.5) |
| Inter-individual variability, % | |||
| Baseline LDL-C | 23.0 | — | (21.9, 24.1) |
| Emax-BA | 36.2 | — | (32.6, 39.4) |
BA, bempedoic acid; CI, confidence interval; ED50-BA, dose of bempedoic acid needed to achieve 50% of maximal effect; Emax-BA, maximal bempedoic acid effect as proportional change from baseline; FIX, model parameter fixed to estimated value without error; HillBA, Hill coefficient for bempedoic acid; kout, first-order rate constant for elimination of LDL cholesterol; LDL-C, LDL cholesterol; SE, standard error.