Table 2.

Univariate and multivariate analysis for associations of SMYD3 protein expression with PFS in DLBCLs.

Variables	Univariate analysis			Multivariate analysis
	HR	95%CI	P-value	HR	95%CI	P-value
SMYD3
Low	1 [Reference]			1 [Reference]
High	2.184	1.369–3.486	0.001*	1.728	1.070–2.791	0.025*
Age
≤60	1 [Reference]
>60	1.016	0.634–1.629	0.947
Sex
Male	1 [Reference]
Female	1.340	0.833–2.155	0.228
Primary site
Nodal	1 [Reference]
Extranodal	1.321	0.810–2.153	0.264
Ann Arbor Stage
I–II	1 [Reference]			1 [Reference]
III–IV	2.725	1.712–4.336	<0.001*	1.942	1.186–3.180	0.008*
IPI scores
Low (0–2)	1 [Reference]			1 [Reference]
High (3–5)	3.661	2.217–6.045	<0.001*	1.541	0.807–2.941	0.190
B symptoms
No	1 [Reference]			1 [Reference]
Yes	1.912	1.196–3.058	0.007*	1.773	1.088–2.887	0.021*
Serum LDH
≤240	1 [Reference]			1 [Reference]
>240	3.230	2.014–5.083	<0.001*	2.365	1.388–4.031	0.002*
Type (IHC)
GCB	1 [Reference]
Non-GCB	0.743	0.469–1.178	0.207

DLBCL Diffuse large B-cell lymphoma, GCB Germinal center B cell, IHC Immunohistochemistry, IPI International Prognostic Index, LDH Lactate dehydrogenase, CI Confidence interval, HR Hazard’s ratio.

^*P values are significant at P < 0.05.