Table 3.

Univariate and multivariate analysis for associations of SMYD3 protein expression with OS in DLBCLs.

Variables	Univariate analysis			Multivariate analysis
	HR	95%CI	P-value	HR	95%CI	P-value
SMYD3
Low	1 [Reference]			1 [Reference]
High	3.119	1.826–5.328	<0.001*	2.645	1.534–4.558	<0.001*
Age
≤60	1 [Reference]
>60	1.007	0.600–1.691	0.978
Sex
Male	1 [Reference]
Female	0.733	0.435–1.237	0.245
Primary site
Nodal	1 [Reference]
Extranodal	1.456	0.859–2.470	0.163
Ann Arbor Stage
I-II	1 [Reference]			1 [Reference]
III-IV	3.157	1.885–5.287	<0.001*	1.521	0.809–2.860	0.193
IPI scores
Low (0–2)	1 [Reference]			1 [Reference]
High (3–5)	4.484	2.620–7.675	<0.001*	2.687	1.466–4.926	0.001*
B symptoms
No	1 [Reference]			1 [Reference]
Yes	1.993	1.187–3.346	0.009*	1.801	1.067–3.040	0.028*
Serum LDH
≤240	1 [Reference]			1 [Reference]
>240	3.043	1.815–5.102	<0.001*	1.740	0.967–3130	0.065
Type (IHC)
GCB	1 [Reference]
Non-GCB	0.604	0.363–1.003	0.051

DLBCL Diffuse large B-cell lymphoma, GCB Germinal center B cell, IHC Immunohistochemistry, IPI International Prognostic Index, LDH Lactate dehydrogenase, CI Confidence interval, HR Hazard’s ratio.

^*P values are significant at P < 0.05.