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. 2022 Sep 3;8:379. doi: 10.1038/s41420-022-01167-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Representative immunohistochemical staining images of NLRP3, caspase-1, cleaved caspase-1 and GSDMD in the kidneys. B Double immunofluorescence staining of glomerular macrophages (green) and GSDMD (red) in each group. F4/80 represented macrophages. C GSDMD in monocytes/macrophages as a proportion of total GSDMD was calculated. D The level of serum IL-1β in each group was detected by ELISA. n = 8 animals for each group. Each experiment was repeated three times. Significant differences were calculated using one-way ANOVA. Values were shown as mean ± SD. **p < 0.01, ***p < 0.001. PIL pristane-induced lupus. DAPI 4′, 6-diamidino-2-phenylindole.