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. Author manuscript; available in PMC: 2022 Sep 4.
Published in final edited form as: Science. 2021 Sep 3;373(6559):eabc1048. doi: 10.1126/science.abc1048

Fig. 3. Cancer competence is reflected by a distinct expression of chromatin-related genes and ATAD2 is a key chromatin factor shared between human PSC-derived melanoblasts and patient melanoma cells.

Fig. 3.

(A) Waterfall plot of the enriched pathways from the GSAA comparing WT melanoblasts to WT melanocytes. Chromatin-related pathways are highlighted in red.

(B) Heatmap depicting the differential expression of chromatin-related genes between WT melanoblasts and WT melanocytes. Normalized log2fold change.

(C) Alteration frequency of the top 25 epigenetic-related factors overexpressed in WT melanoblasts in TCGA SKCM melanoma patient samples.

(D) Kaplan-Meier overall survival curve of TCGA SKCM patients belonging either to the patients group with high levels of ATAD2 expression (ATAD2HI) or with low expression levels (ATAD2LO), log-rank p value reported.