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. 2022 Sep 4;28:102. doi: 10.1186/s10020-022-00530-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Activation of Notch signaling reversed the negative effects of M1 macrophages on osteocyte mineralization. A(i) Alizarin Red S staining images of M1 macrophage-stimulated osteocytes with or without Notch activation; A(ii) the bar graph showed the average OD value of Alizarin Red S staining; OD values were shown as mean ± SD (*p < 0.05, one-way ANOVA); B SEM images of mineralized collagen fibers synthesized from M1 macrophage-stimulated osteocytes with or without activation of Notch signaling pathway (Top: images captured by SE2 mode; Bottom: DDC-SEM images; scale bars represented 1 μm); C Ca/P ratio of mineralized collagen from the above samples detected with EDS; D TEM images and X-ray diffraction patterns demonstrated the ultrastructure of mineralized collagen synthesized by macrophage-stimulated osteocytes with or without Notch signaling pathway activation