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. 2022 Sep 4;20:388. doi: 10.1186/s12967-022-03607-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — M2-polarized microglia promoted the proliferation of irradiated GBM cells by CCL2/CCR2. A M2-polarized HMC3 cells obviously promoted the proliferation of irradiated GBM cells. B GW4869 suppressed the growth of irradiated U251 cells and increased the efficacy of radiotherapy in the co-culture system of U251 and HMC3 cells in a zebrafish model. C GW4869 suppressed the growth of irradiated U87 cells and increased the efficacy of radiotherapy in a co-culture system of U87 and HMC3 cells in a zebrafish model. D The expression of CCR2 increased in U251 cells after radiation. E Knocked down CCR2 significantly relieved the proliferation of the radiated U251 cells by M2 HMC3 cells inducing