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. 2022 Sep 4;20:388. doi: 10.1186/s12967-022-03607-0

Fig. 4.

Fig. 4

circ_0012381 sponged with miR-340-5p to induce the M2 polarization of microglia. A RegRNA 2.0 predicted that circ_0012381 contained a conserved binding site for miR-340-5p. B RT-PCR revealed that circ_0012381 expression was negatively correlated with miR-340-5p expression. C A dual-luciferase reporter assay indicated that miR-340-5p markedly decreased the luciferase activity of wild-type circ_0012381. D miR-340-5p induced the M2 polarization of HMC3 cells. E miR-340-5p inhibited the phagocytic capability of HMC3 cells