Fig. 7.

Dosage R² for all imputed variants and for functional variants when imputing from HD array to WGS level, using the Global Reference Panel (i.e., 289 individuals) and several target sets. Dosage R² for all imputed variants and for functional variants (as annotated by the Ensembl VEP software (LOW, MODERATE and HIGH)) when imputing from HD array to WGS level. The target sets were created by retaining the WGS genotypes that overlapped with the variants of the HD array, from the four available Reference Panels (i.e. Global, African, Asian, and European). These target sets were then used to impute to WGS level using the Global Reference Panel