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Reference
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Participants
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Exposure
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Outcome
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Key Findings
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Comments
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| Garofalo et al, 20118
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Meta-analysis |
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| Bedi, 201012
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62 male Sprague-Dawley rats:
- 31 control supraspinatus repair
- 31 experimental with alpha-2 macroglobulin protein [MMP inhibitor] with identical surgical repair |
alpha-2 macroglobulin (A2 M), a universal MMP inhibitor applied to tendon-bone interface before surgical repair |
Significantly greater fibrocartilage seen at healing enthesis (P < .05), significantly greater collagen organization (P <.01), and a significant reduction in collagen degradation in the A2 M-treated animals compared with controls at 2 weeks (P < .05). |
Local delivery of MMP inhibitor resulted in distinct histologic differences at the tendon-to-bone interface after RCR |
Local delivery of MMP inhibitor in perioperative period may result in a more mature, organized tendon-to-bone interface |
| Rooney, 201813
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165 adult male Sprague-Dawley rats divided into cage activity or exercise groups, and further subdivided into acute and chronic study designs |
The rats were divided into cage activity or exercise therapy consisting of graduated treadmill training and flat treadmill exercise sessions. Half the rats additionally received 10 mg/kg of doxycycline orally every 24 hours functioning as a MMP inhibitor |
Assays included supraspinatus tendon mechanics and histology and muscle fiber morphologic and type analysis |
Doxycycline improved tendon mechanical properties and collagen organization among chronic cage activity group, which was not consistently present in exercised groups. Combined with exercise, doxycycline also decreased average muscle fiber cross-sectional area. |
These results suggest that administration of doxycycline can induce beneficial supraspinatus tendon adaptations without negatively affecting the muscle in caged activity animals, but may not be advantageous when combined with activity |
| Pasternack, 200614
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60 Sprague Dawley rate had their achilles tendons transected transversely |
Doxycycline treatment of 130 mg/kg body weight/ day |
Mechanical evaluation of achilles tendons at 5, 8, and 14 days |
Decreased force of failure (p < 0.005) and energy uptake (p < 0.001) in doxycycline treated group |
Doxycycline serum concentration was clinically relevant at 3.4 (SD 1.0) microg/ml |
