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. 2022 Aug 31;16:2901–2917. doi: 10.2147/DDDT.S354291

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© 2022 Nilsson et al.

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Intratracheal dosing of AZD0449 and AZD4604 showing inhibition of lung inflammation in (A) BALF eosinophils and (B) lung eosinophils, and (C) reduction of the late asthmatic response. Data are shown as bar graphs with mean (n=7–10/group); error bars represent SEM. # denotes statistical significance between saline and OVA-challenged, vehicle-treated rats (P < 0.0001, unpaired t-test with Welch’s correction). Asterisks denote significant differences (*P < 0.05, **P < 0.01, and ***P < 0.001; ANOVA multiple comparisons with Dunnett’s post hoc test for AZD4604 and AZD0449, unpaired t-test with Welch’s correction for model reference budesonide) between OVA-challenged, compound-treated groups and the OVA-challenged, vehicle-treated group.

Abbreviations: ANOVA, analysis of variance; BALF, bronchoalveolar lavage fluid; OVA, ovalbumin; Penh (AUC), average enhanced pause area under the curve.