Table 2.
Summary of IC50s of AZD0449 and AZD4604 in Human and Rat Leukocytes
| Cell Type | Cytokine | STAT/Chemokine | AZD0449 IC50 (nM) | AZD4604 IC50 (nM) |
|---|---|---|---|---|
| Human T cells or monocytes | IFNα | STAT1 | 17.0 | 1.2 |
| Human CD3+ T cells and CD56+ NK cells | IL-12 | STAT4 | 399.0 | 98.0 |
| Human CD4+ T cells | IL-4 | STAT6 | 21.4 | 16.9 |
| Human T cells | IL-2 | STAT5 | 17.8 | 21.0 |
| Rat CD4+ T cells | IL-2 | STAT5 | 17.7 | 28.0 |
| Human CD14+ monocytes | IL-13 | STAT6 | 51.7 | 23.1 |
| Human CD14+ monocytes | TSLP | CCL17 | 81.7 | 57.0 |
Abbreviations: IC50, half maximal inhibitory concentration; IFN, interferon; IL, interleukin; NK, natural killer; STAT, signal transducer and activator of transcription; TSLP, thymic stromal lymphopoietin.