Table 2.
Both Trials | Trial 202 | Trial 203 | ||||||
---|---|---|---|---|---|---|---|---|
Characteristic | All Doses | All Doses | 400 mg | 800 mg | 1200 mg | All Doses | 400 mg | 800 mg |
No. of patients with recurrence on maribavir after clearance | 29 | 25 | 6 | 9 | 10 | 4 | 2 | 2 |
No. of patients with UL97 follow-up genotyping data | 23 | 19 | 5 | 9 | 5 | 4 | 2 | 2 |
Median treatment duration, d | 95 | 111 | 95 | 160 | 76 | 70 | 74 | 57 |
Median starting CMV load, copies/mL | 10 000 | 10 000 | 10 000 | 10 000 | 20 000 | 5500 | 5500 | 6500 |
Median study day at follow-up genotyping | 84 | 86 | 106 | 87 | 83 | 71 | 75 | 62 |
Study day range at follow-up | 52–169 | 70–169 | 85–122 | 71–169 | 70–161 | 52–80 | 69–80 | 52–72 |
UL97 mutation detected, No.a | ||||||||
T409M | 14 (61%) | 10 | 2 | 5 | 3b | 4 | 2 | 2 |
H411Y | 3 (13%) | 3 | 2 | 1 | 0 | 0 | 0 | 0 |
C480F | 6 (26%) | 6 | 0 | 3 | 3b | 0 | 0 | 0 |
T409M, H411Y, or C480F | 22 (96%) | 18 | 4 | 9 | 5 | 4 | 2 | 2 |
Abbreviations: CMV, cytomegalovirus.
aPercentages based on number with available UL97 genotyping data.
bOne patient had UL97 C480F and T409M detected.