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. 2020 Jul 29;226(4):576–584. doi: 10.1093/infdis/jiaa462

Table 2.

UL97 Genotyping Follow-up on Patients With CMV Clearance and Recurrence While on Maribavir

Both Trials Trial 202 Trial 203
Characteristic All Doses All Doses 400 mg 800 mg 1200 mg All Doses 400 mg 800 mg
No. of patients with recurrence on maribavir after clearance 29 25 6 9 10 4 2 2
No. of patients with UL97 follow-up genotyping data 23 19 5 9 5 4 2 2
 Median treatment duration, d 95 111 95 160 76 70 74 57
 Median starting CMV load, copies/mL 10 000 10 000 10 000 10 000 20 000 5500 5500 6500
 Median study day at follow-up  genotyping 84 86 106 87 83 71 75 62
  Study day range at follow-up 52–169 70–169 85–122 71–169 70–161 52–80 69–80 52–72
UL97 mutation detected, No.a
 T409M 14 (61%) 10 2 5 3b 4 2 2
 H411Y 3 (13%) 3 2 1 0 0 0 0
 C480F 6 (26%) 6 0 3 3b 0 0 0
 T409M, H411Y, or C480F 22 (96%) 18 4 9 5 4 2 2

Abbreviations: CMV, cytomegalovirus.

aPercentages based on number with available UL97 genotyping data.

bOne patient had UL97 C480F and T409M detected.