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. 2020 Jul 29;226(4):576–584. doi: 10.1093/infdis/jiaa462

Table 3.

UL97 Genotyping in Nonresponders Who Received >14 Days of Maribavir

Both Trials Trial 202 Trial 203
Characteristic All Doses All Doses 400 mg 800 mg 1200 mg All Doses 400 mg 800 mg 1200 mg
Nonresponders who received maribavir for >14 d 39 26 11 11 4 13 5 5 3
Patients with UL97 follow-up genotyping data 25 16 7 6 3 9 3 4 2
 Median treatment duration, d 55 62 61 59 70 46 45 58 49
 Median starting CMV load, copies/mL 40 000 50 000 50 000 30 000 200 000 14 500 14 500 155 000 11 500
 Median study day at follow-up genotyping 58 59 59 59 58 54 46 68 50
  Study day range at follow-up 15–140 15–140 15–140 47–116 52–91 21–83 46–53 54–83 21–78
UL97 mutation detected, Noa
 T409M 7 (28%) 5 1 3b 1 2 0 2 0
 H411Y 2 (8.3%) 2 1 1 0 0 0 0 0
 C480F 5 (21%) 3 0 3b 0 2 1 0 1
 T409M, H411Y or C480F 13 (52%) 9 2 6 1 4 1 2 1
 F342Y 1 1c

Abbreviation: CMV, cytomegalovirus.

aPercentages based on number with available UL97 genotyping data.

bOne patient had both UL97 C480F and T409M detected.

cThis mutation was present at baseline and later detected in combination with H411YJ.