Table 3.
Both Trials | Trial 202 | Trial 203 | |||||||
---|---|---|---|---|---|---|---|---|---|
Characteristic | All Doses | All Doses | 400 mg | 800 mg | 1200 mg | All Doses | 400 mg | 800 mg | 1200 mg |
Nonresponders who received maribavir for >14 d | 39 | 26 | 11 | 11 | 4 | 13 | 5 | 5 | 3 |
Patients with UL97 follow-up genotyping data | 25 | 16 | 7 | 6 | 3 | 9 | 3 | 4 | 2 |
Median treatment duration, d | 55 | 62 | 61 | 59 | 70 | 46 | 45 | 58 | 49 |
Median starting CMV load, copies/mL | 40 000 | 50 000 | 50 000 | 30 000 | 200 000 | 14 500 | 14 500 | 155 000 | 11 500 |
Median study day at follow-up genotyping | 58 | 59 | 59 | 59 | 58 | 54 | 46 | 68 | 50 |
Study day range at follow-up | 15–140 | 15–140 | 15–140 | 47–116 | 52–91 | 21–83 | 46–53 | 54–83 | 21–78 |
UL97 mutation detected, Noa | |||||||||
T409M | 7 (28%) | 5 | 1 | 3b | 1 | 2 | 0 | 2 | 0 |
H411Y | 2 (8.3%) | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
C480F | 5 (21%) | 3 | 0 | 3b | 0 | 2 | 1 | 0 | 1 |
T409M, H411Y or C480F | 13 (52%) | 9 | 2 | 6 | 1 | 4 | 1 | 2 | 1 |
F342Y | 1 | 1c |
Abbreviation: CMV, cytomegalovirus.
aPercentages based on number with available UL97 genotyping data.
bOne patient had both UL97 C480F and T409M detected.
cThis mutation was present at baseline and later detected in combination with H411YJ.