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Base optimization
| S. No | Base | Equivalents | Yield % |
|---|---|---|---|
| 1 | Na2CO3 | 1.5 | 50 |
| 2 | Na2CO3 | 3.0 | 65 |
| 3 | NaHCO3 | 3.0 | 0 |
| 4 | K2CO3 | 1.5 | 60 |
| 5 | K2CO3 | 3.0 | 70 |
| 6 | Cs2CO3 | 1.5 | 70 |
| 7 | Cs2CO3 | 3.0 | 85 |
| 8 | Triethylamine | 3.0 | 0 |
| 9 | Pyridine | 3.0 | 0 |
| 10 | K2CO3 + Cat. Cs2CO3 | 3.0 | 85 |
*All entries were attempted by using 1.5 equivalent of propargyl bromide, in DMF solvent at 50 °C
