FIG. 1.

A simplified version of the combined physical and genetic map of the S. coelicolor chromosome in the 7-o'clock region, showing the locations of developmental genes and the 21 ordered cosmids that span the strA to hisD interval (adapted from references 36 and 40). The location of whiD is shown on the overlap between cosmids 6G4 and D63, as determined by complementation. The locations of other cloned developmental genes on the cosmid contig are shown on the inside of the circle. The cosmids and their overlaps are arbitrarily shown to be of equal length (the average insert size of the cosmids is 37.5 kb and of the overlaps 12.5 kb [36]). The sizes of the AseI fragments are given in kilobases (27). Symbols: ⧫, oriC; ●, T3 end; ■, T7 end.