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. 2022 Sep 2;5(10):e202201452. doi: 10.26508/lsa.202201452

Figure S4. Mono-allelic expression of TLR7 mRNA is not affected by the parental origin of the X chromosome or by rs179008 or rs3853839 SNPs.

Figure S4.

(A, B) TLR7 mRNA expression at single-cell resolution in mono-allelic pDCs from representative uninfected controls (UC) and HIV/ART women heterozygous for both the SNPs rs179008 (A/T) and rs3853839 (C/G) whom carries the indicated haplotypes T-C/A-G (A) or A-C/T-G (B). Statistical differences in TLR7 mRNA levels were assessed using the Mann–Whitney test. ns, not significant P > 0.05. (C, D) To investigate the impact of each SNP on TLR7 mRNA expression, the median values of TLR7 mRNA expression at single-cell resolution for each allele were plotted from all UC donors (n = 7) and HIV/ART women (n = 5) as indicated, without distinction of haplotypes. Statistical differences in TLR7 mRNA levels according to the rs179008 and rs385839 genotypes were analyzed using the Wilcoxon signed rank test. ns, not significant P > 0.05.