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IC50 shifts initiated by preincubation of the three TKIs with NADPH in CYP2J2 and CYP3A4 incubations.
| TKI | CYP2J2 | CYP3A4 | ||||
|---|---|---|---|---|---|---|
| IC50 | IC50-shift | Fold decrease | IC50 | IC50-shift | Fold decrease | |
| Imatinib | 5.27 ± 0.0656 | 7.43 ± 0.208 | 0.70 | 4.35 ± 0.293 | 2.55 ± 0.370 | 1.9 |
| Gefitinib | 3.72 ± 0.248 | 3.51 ± 0.0930 | 1.06 | 7.72 ± 0.492 | 3.03 ± 0.218 | 2.55 |
| Sunitinib | 397.70 ± 105 | 312.90 ± 9.93 | 1.27 | 10.88 ± 0.450 | 2.73 ± 0.149 | 3.99 |
IC50 values were recorded as μM. Data are reported as the mean ± S.D. of three incubations.
