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. 2022 Aug 22;13:914842. doi: 10.3389/fphar.2022.914842

TABLE 5.

Pharmacokinetic parameters of rivaroxaban per p.o. administration.

Parameter Rivaroxaban Rivaroxaban + imatinib Rivaroxaban + gefitinib Rivaroxaban + sunitinib
AUC(0-t) 1.547 ± 0.268 2.946 ± 0.647 * 1.587 ± 0.145 0.583 ± 0.101 **
Cmax 129.7 ± 22.70 281.4 ± 54.05 ** 106.8 ± 23.60 35.60 ± 2.426 **
Tmax 4 3 3 4

AUC(0-t) was recorded as ug/mL·h, Cmax was recorded as ng/mL, and Tmax was recorded as h. Data are expressed as the mean ± S.D.

*

p < 0.05.

**

p < 0.01 compared with control; n = 5.