TABLE 1.
Overview of LncRNAs related to the enzymes of aerobic glycolysis in cancer.
| Enzyme | LncRNAs | Target | Function | Cancer type |
|---|---|---|---|---|
| Pyruvate kinase M2 (PKM2) | LncRNA-FEZF1-AS1 | PKM2/STAT3 | Increase the stability and expression level of PKM2 in cytoplasmic and nucleus, promote colorectal cancer cell proliferation and metastasis | Colorectal cancer |
| LncRNA-WFDC21P | PKM2/HIF1α | Bind to PKM2 and suppress its transcriptional activity, inhibit hepatocellular carcinoma cell’s proliferation and metastasis | Hepatocellular carcinoma | |
| LncRNA-HOXB-AS3 | hnRNP A1/PKM2 | Ensure the formation of lower PKM2, suppress colon cancer growth | Colon cancer | |
| Linc01554 | PI3K/Akt/mTOR | Regulate ubiquitin-mediated degradation of PKM2, suppress hepatocellular carcinoma cancer cell growth | Hepatocellular carcinoma | |
| LncRNA-SOX2OT | miR-122-5p | Upregulate PKM2, promote hepatocellular carcinoma cancer cell metastasis | Hepatocellular carcinoma | |
| Lactate dehydrogenase A (LDHA) | LncRNA-IGFBP4-1 | IGFBP4 | Upregulate LDHA expression, promote lung cancer progression | Lung cancer |
| LncRNA HULC | FGFR1 | Elevate phosphorylation and activity of LDHA, enhance hepatocellular carcinoma cancer cell proliferation | Hepatocellular carcinoma | |
| LncRNA ANRIL | PI3K/Akt/mTOR | Upregulate the expression of LDHA, promote nasopharyngeal carcinoma progression | Nasopharyngeal carcinoma | |
| LncRNA RAET1K | miR-100-5p | Upregulate the expression of LDHA, promote hepatocellular carcinoma cell metastasis | Hepatocellular carcinoma | |
| Hexokinase 2 (HK2) | LncRNA PVT1 | miR-497 | Enhance the expression of HK2, promote osteosarcoma cell proliferation | Osteosarcoma |
| LncRNA C1QTNF1 | miR-484 | Increase HK2 expression, promote colorectal cancer cell proliferation, migration, and invasion | Colorectal cancer | |
| LncRNA DUXAP8 | miR-409-3p | Regulate HK2 expression, promote non-small-cell lung cancer cell growth, metastasis | Non-small-cell lung cancer | |
| LncRNA UCA1 | mTOR-STAT3/miR-143 | Mediate the regulation of UCA1 to HK2, exert promotion effects on tumorigenesis in bladder cancer | Bladder cancer | |
| LncRNA BCAR4 | Hedgehog | Enhance the transcription of HK2, facilitate tumorigenesis in breast cancer | Breast cancer | |
| Glucose transporter1 (GLUT1) | LncRNA HOTAIR | PI3K/Akt/mTOR | induce GLUT1 expression, promote hepatocellular carcinoma cell proliferation | Hepatocellular carcinoma |
| LncRNA NBR2 | AMPK | Down-regulate GLUT-1 expression and the EMT process, suppress tumor progression in osteosarcoma cell | Osteosarcoma | |
| LncRNA SLC2A1-AS1 | STAT3 | Negatively regulate GLUT1 expression, decrease the proliferation and metastasis of hepatocellular carcinoma cells | Hepatocellular carcinoma | |
| Lnc-P23154 | miR-378a-3p | Enhance GLUT1 expression and promote oral squamous cell carcinoma metastasis | Oral squamous cell carcinoma | |
| LncRNA RAD51-AS1 | miR-29b/c-3p | Inhibit the expression of GLUT1, inhibit proliferation, invasion and glycolytic metabolism of colorectal cancer cell | Colorectal cancer | |
| LncRNA XIST | miR-126/IRS1/PI3K/Akt | Elevate the expression of GLUT1, promote glioblastoma cell viability, migration, invasion, and resistance to apoptosis | Glioblastoma |