FIGURE 2.

Score plots of lipid changes across species. Partial least squares-discriminant analysis (PLS-DA) showed strain-dependent separation of lipid species between the SD (red) and HFD mice (blue); dots represent individual mice. BL6 mice with weight gain, dyslipidemia, and both large fiber and small fiber PN (A) and BTBR mice with weight gain and large-fiber PN (B) showed distinct separation of sciatic nerve (SCN) lipids between SD and HFD groups compared to BKS mice with large fiber PN without weight gain (C). Whereas, clear separation between plasma (D–F) and liver lipids (G–I) was visible across murine strains.