Figure 5.

CAQK homes to demyelinating lesions in the mouse model of experimental autoimmune encephalomyelitis (EAE). (A) Disease scores over a 28-day period show EAE progression with an average 7-day onset and a 14-day peak. Control mice show no disease. (B) FAM-CAQK (green) accumulates at lesion sites in the lumbar spinal cords of mice with EAE. Lesions are indicated by clusters of DAPI-stained nuclei (blue) in (C) representing invasions of peripheral inflammatory cells, prominently T-cells and macrophages, into the spinal cord parenchyme. Merged images are shown in (D). Continuous line delimitates the spinal cord tissue. The dotted line indicates area of active EAE lesion. Scale bar: 50 μm.