Figure 3.

Trend plots illustrating CSF tracer enrichment in selected brain regions of non-dementia subjects with good or poor sleep quality. For patient cohort #1 with no diagnosed dementia disease, trend plots of percentage change in normalized T1 signal units from baseline, indicative of extra-vascular cerebral tracer enrichment in (a) gray matter of entorhinal cortex, (b) white matter within entorhinal cortex, (c) gray matter of insular cortex, (d) white matter within insular cortex, (e) gray matter of cingulate cortex, (f) white matter within cingulate cortex, (g) amygdala and (h) hippocampus. Significant differences between the Poor sleepers (red line) and Good sleepers (blue line) are indicated as follows: *P < 0.05, **P < 0.01, ***P < 0.001. Trend plots show mean with error bars (95% confidence intervals) from linear mixed models.