Figure 5.

Dabigatran prevents α-thrombin-induced increase in microvessel permeability to IgG. In a factorial design, stereotaxic injection of either placebo (–) or α-thrombin (+) into the mouse striatum significantly increased IgG extravasation into the neuropil from the microvasculature in animals receiving α-thrombin and placebo chow (see inset (arrow) photomicrographs of immunoreactive IgG in matched fields). Dabigatran-containing chow significantly reduced IgG extravasation (white bar) compared to the placebo chow (black bar). A GLM analysis found a significant α-thrombin effect (p = 0.001), a significant dabigatran effect (p < 0.001), and a large α-thrombin × dabigatran interaction (p = 0.0002). A total of 31 animals received placebo-containing chow (n = 15) or dabigatran-containing chow (n = 16). Magnification bar=100 µm.