Table 2.
Whole brain and regional volumes (mL).
| Healthy controls (16) | Fragile Xsubjects (10) | |
|---|---|---|
| Whole brain | 1433.9 ± 170.4 | 1337.4 ± 77.2 |
| Frontal cortex | 181.4 ± 19.0 | 165.1 ± 18.2* |
| Parietal cortex(Inferior parietal lobule) | 29.5 ± 3.3 | 29.4 ± 4.0 |
| Cingulate cortex | 19.7 ± 2.8 | 18.2 ± 3.2 |
| Hippocampus | 8.2 ± 1.0 | 7.8 ± 1.4 |
| Amygdala | 1.3 ± 0.3 | 1.2 ± 0.2 |
| Thalamus | 14.5 ± 2.1 | 13.9 ± 2.1 |
| Caudate | 8.5 ± 1.5 | 9.3 ± 1.5 |
| Putamen | 8.8 ± 1.2 | 8.5 ± 0.8 |
| Corona radiata (sampled volume) | 5.5 ± 0.7 | 5.4 ± 0.7 |
Values are the means ± SD for the number of subjects indicated in parentheses.
Data from the regional analysis were subjected to a mixed model ANOVA with region as a within subject variable and diagnosis as a between subject variable. The region x diagnosis (F8,192 = 4.238, p = 0.042) interaction was statistically significant. *, Post-hoc Bonferroni-corrected multiple comparison results indicate that volume in frontal cortex was statistically significantly lower (−9%) in subjects with FXS. Whole brain volumes were analyzed separately by means of an unpaired t-test. Difference was not statistically significant (t = 1.676, df = 24, p = 0.107).