TABLE 5.

Subgroup analyses.

	Subgroups	MACE				HF related rehospitalization
		Patient’s num.	RR (95% CI)	P	I 2	Patient’s num.	RR (95% CI)	P	I 2
Conditions	AHF	473	0.64 (0.50–0.83)	0.001	87.3	473	0.70 (0.49–0.99)	0.041	85.4
	CHF	693	0.53 (0.39–0.71)	0.000	0	693	0.55 (0.37–0.82)	0.003	36.9
Age (yr)	< 70.0	574	0.54 (0.44–0.67)	0.000	0	574	0.56 (0.40–0.79)	0.001	50.2
	≥ 70.0	592	0.73 (0.48–1.10)	0.133	69.3	592	0.73 (0.48–1.10)	0.133	69.3
AF (%)	< 27.2	595	0.53 (0.43–0.67)	0.000	0	595	0.47 (0.33–0.67)	0.000	0
	≥ 27.2	571	0.72 (0.50–1.05)	0.089	56.6	571	0.93 (0.62–1.41)	0.731	48.1
DM (%)	< 38.3	843	0.61 (0.50–0.76)	0.000	65.7	843	0.61 (0.45–0.82)	0.001	63.5
	≥ 38.3	323	0.48 (0.29–0.79)	0.004	0	323	0.69 (0.39–1.21)	0.194	56.0
Ischemic HF (%)	< 44.2	696	0.61 (0.48–0.76)	0.000	66.5	696	0.71 (0.53–0.96)	0.027	72.3
	≥ 44.2	470	0.55 (0.38–0.79)	0.001	0	470	0.45 (0.26–0.76)	0.003	0
LVEF (%)	< 37.5	470	0.52 (0.37–0.75)	0.000	14.3	470	0.40 (0.24–0.69)	0.001	0
	≥ 37.5	696	0.62 (0.49–0.78)	0.000	62.6	696	0.75 (0.55–1.00)	0.053	66.4
TnI (ng/ml)	< 1.23	451	0.54 (0.42–0.67)	0.000	0.3	451	0.45 (0.30–0.67)	0.000	0
	≥ 1.23	715	0.67 (0.48–0.94)	0.019	57.5	715	0.81 (0.57–1.15)	0.234	59.7
eGFR (ml/min/1.73°m2)	< 48.8	470	0.52 (0.37–0.75)	0.000	14.3	470	0.40 (0.24–0.69)	0.001	0
	≥ 48.8	696	0.62 (0.49–0.78)	0.000	62.6	696	0.74 (0.55–1.00)	0.053	66.4
B-lines	< 5.0	493	0.56 (0.42–0.77)	0.000	0	493	0.63 (0.41–0.96)	0.032	49.5
	≥ 5.0	673	0.60 (0.47–0.77)	0.000	67.3	673	0.62 (0.45–0.87)	0.005	67.7
NT-proBNP (pg/ml)	< 3,433	592	0.51 (0.40–0.64)	0.000	0	592	0.56 (0.41–0.77)	0.000	58.4
	≥ 3,433	574	0.76 (0.64–1.07)	0.112	51.7	574	0.77 (0.48–1.24)	0.284	55.6
Follow-up (m)	< 4.7	692	0.66 (0.44–0.98)	0.038	64.4	692	0.65 (0.44–0.97)	0.036	66.5
	≥ 4.7	474	0.56 (0.45–0.69)	0.000	0	474	0.61 (0.43–0.85)	0.004	51.6