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. 2022 Sep 2;9:39. doi: 10.1186/s40580-022-00330-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Working principle of the dual-mode SERS-LFA strip for simultaneous detection of SARS-CoV-2 and influenza A virus. a Preparation of virus lysates in a nasopharyngeal solution of normal individuals. This virus solution was mixed with SERS nanotags and a running buffer solution in a 96-well plate. b N-protein antibody-conjugated SERS nanotags for the detection of SARS-CoV-2 and influenza A virus. c SERS nanotags and running buffer move toward the SERS-LFA strip by capillary force. Formation of sandwich immunocomplexes for SARS-CoV-2 (test line 1) and influenza A virus (test line 2)