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. 2022 Sep 2;9:39. doi: 10.1186/s40580-022-00330-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Pixel-to-pixel SERS detections for an area of 2600 μm × 500 μm with a 100 μm interval for test and control lines. Raman signal intensities for 130 spots were averaged to obtain reliable Raman signal intensity. b Visual color changes of the SERS-LFA strip and corresponding SERS spectra of the test and control lines when the concentration of SARS-CoV-2 lysate changed in the range of 0–1000 PFU/mL. c Visual color changes of the SERS-LFA strip and corresponding SERS spectra of the test and control lines when the concentration of influenza A virus lysate changed in the range of 0–8064 HAU/mL