Table 5.
Univariate and multivariate Cox regression analyses for recurrence-free survival time in ampullary adenocarcinoma patients after Whipple’s resection
| Characteristic | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|
|
|
|
|||
| HR [95% CI] | P-value | HR [95% CI] | P-value | |
| Sex | ||||
| Male | Reference | |||
| Female | 1.180 [0.774-1.800] | 0.442 | ||
| Age | ||||
| ≤48 | Reference | |||
| >48 | 0.796 [0.479-1.323] | 0.379 | ||
| Jaundice | ||||
| No | Reference | |||
| Yes | 1.279 [0.753-2.171] | 0.363 | ||
| Intraoperative transfusion | ||||
| No | Reference | Reference | ||
| Yes | 0.683 [0.448-1.042] | 0.077 | 0.668 [0.430-1.040] | 0.074 |
| Operation time | ||||
| ≤6 hours | Reference | |||
| >6 hours | 1.097 [0.677-1.777] | 0.708 | ||
| Tumor size | ||||
| ≤2.2 cm | Reference | Reference | ||
| >2.2 cm | 1.611 [1.059-2.453] | 0.026 | 1.330 [0.845-2.091] | 0.217 |
| Differentiation | ||||
| Poor | Reference | Reference | ||
| Moderate | 0.720 [0.454-1.144] | 0.164 | 1.063 [0.633-1.786] | 0.817 |
| Well | 0.350 [0.189-0.649] | 0.001 | 0.807 [0.381-1.706] | 0.574 |
| Regional nodes examined | ||||
| ≤11 | Reference | Reference | ||
| >12 | 1.524 [0.996-2.333] | 0.052 | 0.980 [0.595-1.615] | 0.937 |
| T stage | ||||
| T1 | Reference | Reference | ||
| T2 | 1.969 [0.864-4.488] | 0.107 | 1.696 [0.704-4.084] | 0.239 |
| T3 | 4.205 [1.898-9.312] | <0.001 | 2.656 [1.079-6.541] | 0.034 |
| N stage | ||||
| N0 | Reference | Reference | ||
| N1 | 2.071 [1.294-3.316] | 0.002 | 1.105 [0.616-1.985] | 0.737 |
| N2 | 2.888 [1.240-6.728] | 0.014 | 1.523 [0.543-4.274] | 0.424 |
| Lymphovascular invasion | ||||
| No | Reference | Reference | ||
| Yes | 3.310 [2.005-5.463] | <0.001 | 1.953 [1.050-3.633] | 0.035 |
| Postoperative complications | ||||
| No | Reference | |||
| Yes | 1.026 [0.660-1.594] | 0.911 | ||
| Adjuvant treatment | ||||
| No | Reference | Reference | ||
| Yes | 2.481 [1.579-3.900] | <0.001 | 1.243 [0.658-2.348] | 0.502 |