Figure 5.

PYCR1 expression was upregulated in advanced ccRCC. A. Higher PYCR1 expression was associated with worse clinical parameters in ccRCC patients, such as histological grade, stage, T stage, N stage, and M stage according to data from the TCGA. B. PYCR1 expression was significantly higher in high-stage ccRCC in GSE73731 (P = 0.016) and GSE66272 (P = 0.043). C. PYCR1 expression was significantly higher in high-grade ccRCC in GSE73731 (P = 2.434e-04) and GSE66272 (P = 0.020). D. Difference in the proportion of cases with different grades (Chisq Test, P = 0.019) from GSE73731 between the high and low-PYCR1 expression subgroups. E. Differences in the protein expression of PYCR1 between ccRCC and normal tissues (P = 7.69e-19). F. Diagnostic value of PYCR1. An AUC value of 0.742 suggested that PYCR1 had a significant predictive value.