Table 2.
Exploring the pathogenesis of ovarian AGCT
| Pathway/Factor | In vitro | In vivo | Ref. |
|---|---|---|---|
| Notch signalling pathway | KGN cell line | [126,127] | |
| BMP signalling pathway | BMPr1a-/- mice, BMPr1b-/- mice | [128,129] | |
| SMAD 4 | SMAD4loxp/loxp AMHR2 Cre mice | [130] | |
| FOXL2-SMAD4 | SMAD4-/-FOXL2-/- mice, FSHD-/- mice | [131] | |
| NFKB signalling pathway | KGN cell line | [132] | |
| PI3K/AKT signalling pathway | FOXO1/3-/- mice | [133] | |
| PI3K/AKT signalling pathway and Wnt signalling pathway | Ptenflox/flox, AMHRcre/+ mice | [133] | |
| GATA4 | KGN cell line | [58,134] | |
| Inhibin | Inhα-/- mice | [135] | |
| Estrogen/FOXL2 signalling pathway | FOXL2-/- KGN cell line; KGN cell line; COV434 cell line | [80] | |
| GATA4-Bcl-2 | KK-1 cell line; COS-7 cell line; KGN cell line | [136] | |
| Activin A/PI3K signalling pathway | Cre+ mice | [137] | |
| Activin/SMAD2/3 signalling pathway | SMAD3-/- mice | [138] |