Table 2.

Studies on radiotherapy alone instead of breast surgery after neoadjuvant chemotherapy

Study	Period	Type	n	Treatment	Follow-up	OS or DFS	LRR
Daveau [70]	1985-1989	retrospective	165 cCR	65 Surgery	12 years	RT vs Surgery	RT vs Surgery
				100 RT		5-year 91% vs 82%	31% vs 17%
						10-year 77% vs 79%
L.Mauriac [68]	1985-1989	retrospective	272	A: 138 initial surgery	124 months	NS in DFS and RFS	22.5% BCS+RT,
			44 cCR	B: 134 NAC:			22.4% Mastectomy
				40 BCS+RT,			34% RT
				49 mastectomy
				44 RT
Ring [67]	1986-1999	retrospective	453,	69 RT	RT vs Surgery	RT vs Surgery	RT vs Surgery
			136 cCR	47 Surgery	87 months vs 67 months	DFS and OS.	21% vs 10%
						5-year 76% vs 74%
						10-year 70% vs 60%
Perloff [92]	1978-1983	retrospective	87	43 Surgery	39 months	RT vs Surgery	RT vs Surgery
				44 RT		63% vs 50%	27% vs 19%
Scholl [69]	1986-1990	retrospective	200	36 mastectomy ± RT,	66 months	-	-
				62 BCS+RT
				102 RT
Clouth [71]	2000-2005	retrospective	101,	16 RT	33.5 months	NS in DFS or OS.	9.5% surgery;
			16 pCR	84 surgery			12.5% non-surgery.

Abbreviations: OS, overall survival; DFS, disease-free survival; LRR, locoregional recurrence rate; NAC, neoadjuvant chemotherapy; pCR, pathological complete response; cCR, clinical complete response; RT, radiotherapy treatment; BCS, breast-conserving surgery; NS, no significant.