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. 2022 Aug 22;13:956340. doi: 10.3389/fimmu.2022.956340

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Copyright © 2022 Loureiro, Moura-Neto, Martins, Silva, Lopes, Leitão, Coelho-Aguiar, Moura-Neto, Warren, Costa and Brito

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TcdA and TcdB upregulate P2X7R expression in EGCs. (A) Gene expression of P2X7R were evaluated by qPCR in EGCs incubated with DMEM only (control), TcdA (50 ng/mL) and TcdB (1 ng/mL). The data are the mean ± SEM. Two-way ANOVA followed by the Tukey test was used. (B) Fluorescence intensity of P2X7R immunostaining in EGCs measured by ImageJ software. The data are the mean ± SEM. One-way ANOVA followed by the Tukey test was used. p value is represented in the graph (C) Representative photomicrographs of P2X7R (green) immunostaining and DAPI (blue) nuclear staining in EGCs exposed to TcdA and TcdB after 18 h of incubation.