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. 2022 Aug;11(8):1398–1407. doi: 10.21037/tp-22-410

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2022 Translational Pediatrics. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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NMS induced adolescent visceral pain, anxiety- and depression-like behaviors. (A) NMS decreased visceral pain threshold on P40 and P60. (B) NMS decreased sucrose intake percentage compared to the control group on P40 and P60. (C) Representative open field photos. (D-F) NMS decreased center distance and center time compared to the control group, and the total distance did not differ from the control group on P40 and P60. All data were expressed as mean ± SD, *, P<0.05. NMS, neonatal maternal separation.