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. 2022 Aug;11(8):1398–1407. doi: 10.21037/tp-22-410

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2022 Translational Pediatrics. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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EE biased adolescent brain mPFC, BLA, and PVN towards anti-inflammatory features. (A-C) ELISA results showed that NMS mice in the EE group decreased the expression of TNF-α and IL-1β in mPFC, BLA, and PVN, and increased the expression of IL-10 in mPFC, BLA, and PVN on P40 and P60 compared with the group without EE. All data were expressed as mean ± SD. *, P<0.05; **, P<0.01. mPFC, medial prefrontal cortex; EE, environmental enrichment; BLA, basolateral amygdala; PVN, paraventricular nucleus; TNF-α, tumor necrosis factor-α; IL-1β, interleukin-1β; IL-10, interleukin-10; ELISA, enzyme linked immunosorbent assay; NMS, neonatal maternal separation; SD, standard deviation.