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. 2022 Jul 7;23(9):e55299. doi: 10.15252/embr.202255299

Figure EV3. Metabolic changes in early‐transient control mice.

Figure EV3

  • A, B
    Principal component analysis (PCA) (A) and heatmap (B) of liver metabolomic profile from P4‐P30 (green samples) and P30‐P60 (red samples) mice treated with vehicle.
  • C
    Volcano plots showing the metabolomic changes in P4‐P30 compared with P30‐P60 mice treated with vehicle. Each circle represents one metabolite. The log2 fold change is represented on the x‐axis. The y‐axis shows the ‐log10 of the FDR. A FDR of 0.1 is indicated by gray line. Gray, pink, and light blue dots represent unchanged, significantly downregulated, and significantly upregulated metabolites, respectively. Blue dots represent significantly upregulated bile acids in P4‐P30 compared to P30‐P60 mice treated with vehicle.
  • D, E
    Principal component analysis (PCA) (D) and heatmap (E) of liver metabolomic profile from P4‐P30 (green samples) and P30‐P60 (red samples) mice transiently treated with vehicle and analyzed at P350. F, female; M, male.