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. 2022 Aug;14(8):3016–3029. doi: 10.21037/jtd-22-897

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2022 Journal of Thoracic Disease. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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LncRNAs related to drug resistance against lung cancer and their mechanism of action. Red arrow: inhibition; green arrow: promoting effect; red represents the inhibition of drug-resistant LncRNAs; green signifies the promotion of drug resistance of LncRNAs. LncRNAs, long-chain non-coding RNA; EGFR, epidermal growth factor receptor; MEG3, maternal expression gene 3; Akt, protein kinase B; mTOR, mammalian target of rapamycin; EMT, epithelial-mesenchymal transition; Wnt, wingless/integrated; MALAT1, metastasis-associated lung adenocarcinoma transcript 1; MDR1, multidrug resistance 1; MRP1, multidrug resistance-related protein 1.