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. 2022 Aug;14(8):3016–3029. doi: 10.21037/jtd-22-897

Table 2. Abnormal expression of LncRNAs in lung cancer.

LncRNAs Expression Regulatory mechanism Effect References
SCAL1 Upregulated Not available Anti-oxidation (26,27)
MALAT1 Upregulated miR-124/STAT3
miR-206/AKT
miR-185-5p/MDM4
Facilitate diffusion and invasion, proliferation, and migration (28–33)
ANRIL Upregulated EZH2
p15
Promote proliferation and inhibit apoptosis (34–39)
H19 Upregulated miR-17/STAT3
miR-484/ROCK2/JNK
miR-196b/LIN28B
Promote proliferation, migration, invasion, EMT (40–43)
DLX6-AS1 Upregulated miR-27b-3p/GSPT1 Promote proliferation and inhibit apoptosis (44,45)
miR-144/PRR11
PVT1 Upregulated miR-497
miR-200a(b)/MMP9
miR-128/VEGFC
miRNA-526b/EZH2
Promote proliferation, invasion and inhibit apoptosis (46–48,50,51)
HOTAIR Upregulated miR-203
miR-149-5p
Promote progression (53–55)
GAS5 Downregulated IGF-1R/IGF-1
miR-221-3p/IRF2
Inhibit proliferation, invasion, migration, EMT and induce apoptosis (57–62)
MEG3 Downregulated P53
miR-7-5p/ BRCA1
miR-543/IDO
Inhibit proliferation and induce apoptosis (65-68)
BANCR Downregulated MAPK/JNK Inhibition of proliferation, migration, and invasion (69–72)
MIR22HG Downregulated YBX1, MET, p21 Suppress tumor (74,75)
PICART1 Downregulated AKT1
JAK2/STAT3
Suppress cell growth, invasion proliferation and induce apoptosis (76,77)
PANDAR Downregulated BECN1
NF-YA/Bcl-2
Inhibit proliferation, promote apoptosis (78,79)