Table 2. Abnormal expression of LncRNAs in lung cancer.
| LncRNAs | Expression | Regulatory mechanism | Effect | References |
|---|---|---|---|---|
| SCAL1 | Upregulated | Not available | Anti-oxidation | (26,27) |
| MALAT1 | Upregulated | miR-124/STAT3 miR-206/AKT miR-185-5p/MDM4 |
Facilitate diffusion and invasion, proliferation, and migration | (28–33) |
| ANRIL | Upregulated | EZH2 p15 |
Promote proliferation and inhibit apoptosis | (34–39) |
| H19 | Upregulated | miR-17/STAT3 miR-484/ROCK2/JNK miR-196b/LIN28B |
Promote proliferation, migration, invasion, EMT | (40–43) |
| DLX6-AS1 | Upregulated | miR-27b-3p/GSPT1 | Promote proliferation and inhibit apoptosis | (44,45) |
| miR-144/PRR11 | ||||
| PVT1 | Upregulated | miR-497 miR-200a(b)/MMP9 miR-128/VEGFC miRNA-526b/EZH2 |
Promote proliferation, invasion and inhibit apoptosis | (46–48,50,51) |
| HOTAIR | Upregulated | miR-203 miR-149-5p |
Promote progression | (53–55) |
| GAS5 | Downregulated | IGF-1R/IGF-1 miR-221-3p/IRF2 |
Inhibit proliferation, invasion, migration, EMT and induce apoptosis | (57–62) |
| MEG3 | Downregulated | P53 miR-7-5p/ BRCA1 miR-543/IDO |
Inhibit proliferation and induce apoptosis | (65-68) |
| BANCR | Downregulated | MAPK/JNK | Inhibition of proliferation, migration, and invasion | (69–72) |
| MIR22HG | Downregulated | YBX1, MET, p21 | Suppress tumor | (74,75) |
| PICART1 | Downregulated | AKT1 JAK2/STAT3 |
Suppress cell growth, invasion proliferation and induce apoptosis | (76,77) |
| PANDAR | Downregulated | BECN1 NF-YA/Bcl-2 |
Inhibit proliferation, promote apoptosis | (78,79) |