Figure 4.

Summary of features considered atypical for MS.

Features considered atypical for MS, in both MOG-IgG positive and MOG-IgG negative participants meeting MS diagnostic criteria. For each serologically defined subgroup, the atypical features are shown at presentation, during the disease course, and at time of their most recent brain MRI scan. As shown in the intersections of the two Venn diagrams, the majority (10/12) of MOG-IgG positive participants exhibited atypical features from initial presentation and throughout their disease course including their most recent MRI, while none (0/53) of the MOG-IgG negative MS patients exhibited any of these atypical features throughout their course.

*Minimal lesion load at last MRI evaluation was defined as total T2 lesion volume >0 and <1cc.