Table 3.
Red flags prompting evaluation of MOG-IgG antibody status in children meeting MS diagnostic criteria.
| Sensitivity (95% CI) | Specificity (95% CI) | |
|---|---|---|
| Presenting features | ||
| Age at onset <11 years | 0.92 (0.62–1.0) | 0.89 (0.77–0.96) |
| Normal brain MRI or exclusively small non-specific lesions | 0.45 (0.17–0.77) | 1.00 |
| Large brain lesions with ill-defined borders | 0.55 (0.23–0.83) | 0.92 (0.80–0.98) |
| Diffuse confluent bilateral lesion pattern | 0.27 (0.6–0.61) | 1.00 |
| Disease course | ||
| Relapses restricted to the optic nerve | 0.25 (0.05–0.57) | 0.98 (0.90–1.00) |
| Complete or near complete resolution of initial MRI T2 lesions a | 0.75 (0.35–0.97) | 0.89 (0.77–0.96) |
| Absence of new T2 lesions after 1 year from presentation (in patients not treated with high efficacy DMTs) | 0.73 (0.39–0.94) | 0.88 (0.73–0.97) |
a
Defined as normal brain MRI or total T2 lesion volume >0 and <1cc at last MRI evaluation.