Table 2.

Second-generation antihistamines and effects on the central nervous system.

Drug	Doses mg	Sedation observed in studies on rhinitis or urticaria, alone
Bilastine	20	1.8–5.8%
Cetirizine	10	6–8.5%
Desloratadine	5	1.1–3.7%
Ebastine	10	1.4–2.7%
	20	<2–3%
Fexofenadine	120	<2–3%
	180	1.7–4.5%
Levocetirizine	5	0.7–6.7%
Loratadine	10	2.2–6.6%
Rupatadine	10	2.7–10%

Adapted from Simons and Simons.²