TABLE 2.
Phenotypic revertants of vanA mutants
| Parental strain | Phenotypic revertant | Gene designation | Nucleotide substitution | Amino acid substitution | No. of isolates | Phenotype |
|---|---|---|---|---|---|---|
| ADP9200 | vanA9200 | A917C | Q306P | |||
| ADP9299 | vanA9299 | C916T | P306S | 1 | Wild type | |
| ADP9204 | vanA9204 | T649A | W217R | |||
| Wild type | A649T | R217W | 6 | Wild type | ||
| ADP9207 | vanA9207 | T660G | C220W | |||
| Wild type | G660T | W220C | 5 | Wild type | ||
| ADP9207 | vanA9207 | T660G | C220W | |||
| ADP9307 | vanA9307 | T658G | W220G | 1 | Increased affinity for inhibitors | |
| ADP9210 | vanA9210 | T683A | V228D | |||
| Wild type | A683T | D228V | 6 | Wild type | ||
| ADP9210 | vanA9210 | T683A | V228D | |||
| ADP9310 | vanA9210 | A394T | S132C | 1 | Wild type | |
| ADP9211 | vanA9211 | T595C | W199R | |||
| Wild type | C595T | R199W | 6 | Wild type | ||
| ADP9213 | vanA9213 | A556C | T186P | |||
| ADP9313 | vanA9313 | C556T | P186S | 6 | Wild type | |
| ADP9222 | vanA9222 | C982T | Q328stop | |||
| Wild type | T982C | Stop328Q | 3 | Wild type | ||
| ADP9222 | vanA9222 | C982T | Q328stop | |||
| ADP9322 | vanA9322 | T982A | Stop328K | 2 | Wild type | |
| ADP9222 | vanA9222 | C982T | Q328stop | |||
| ADP9323 | vanA9323 | A983T | Stop328L | 1 | Wild type |