Table 3.
Univariate and multivariate analysis of the relationship between the variables included in the clinical decision rule and the frequency of pharyngocutaneous fistula.
| Variables | All n (%) |
With fistula n (%) |
Without fistula n (%) |
Univariate analysis p-Value |
Multivariate analysis p-Value |
|---|---|---|---|---|---|
| ASA | |||||
| 2 | 107 (63) | 25 (51.1) | 82 (68) | 0.05a | 0.005 |
| 3 | 62 (36.2) | 23 (48.9) | 39 (32) | ||
| Alcohol | |||||
| Heavy | 126 (73.7) | 38 (79.2) | 88 (71.5) | 0.34a | 0.361 |
| Hemoglobin pre | |||||
| <12.4 g/dL | 65 (39.6) | 22 (48.9) | 43 (36.1) | 0.15a | 0.665 |
| Albumin pre | |||||
| <37.0 g/L | 30 (34.1) | 7 (25) | 23 (38.3) | 0.24a | 0.07 |
| Co morbidities | |||||
| DM | 25 (14.6) | 8 (16.7) | 17 (13.8) | 0.63a | 0.72 |
| COPD | 18 (10.5) | 3 (6.2) | 15 (12.2) | 0.4a | |
| Liver disease | 39 (22.8) | 11 (22.9) | 28 (22.8) | 1a | |
| Cardiopathy | 42 (24.6) | 11 (22.9) | 31 (25.2) | 0.85a | |
| N | |||||
| N0 | 83 (48.6) | 21 (43.8) | 62 (50.4) | 0.25b | 0.933 |
| N1 | 25 (14.6) | 8 (16.7) | 17 (13.8) | ||
| N2a + N2b + N2c | 58 (33.9) | 17 (9.94) | 41 (23.96) | ||
| N3 | 5 (2.9) | 2 (1.16) | 3 (1.74) | ||
| Location | |||||
| Larynx | 67 (39.2) | 18 (10.5) | 49 (28.6) | 0.86a | 0.539 |
| Pharyngolaryngeal | 104 (60.8) | 30 (62.5) | 74 (60.2) | ||
| Rt pre | |||||
| Yes | 12 (7.0) | 4 (8.3) | 8 (6.5) | 0.74a | |
| CRT pre | |||||
| Yes | 15 (8.8) | 9 (18.8) | 6 (4.9) | 0.01a | 0.120 |
| Tracheotomy pre | |||||
| Yes | 77 (45) | 28 (58.3) | 49 (39.8) | 0.04a | 0.144 |
Rt, radiotherapy; CRT, chemoradiotherapy; pre, preoperative; DM, diabetes mellitus; COPD, chronic obstructive pulmonary diseases.
a
Fisher's exact test.
b
Chi-squared test.