Table 4.
Incidence, latency, and duration of FN with bacteriology post-PBI/BM5.
| Exposure | Treatment | Incidence of FN (% of NHP) | First Day of FN | # of Days | Incidence of Infection (% of Cultured NHP) | |
|---|---|---|---|---|---|---|
| Gram+ | Gram− | |||||
| 10.0 Gy | Control (n=15) | 47% | 15.9 ± 2.8 | 1.1 ± 0.1 | 29% | 0% |
|
| ||||||
| Neupogen® on day 1 (n=7) |
14% (n=1) | 4 | 1 | 0% | 0% | |
|
| ||||||
| Neupogen® on day 3 (n=8) | 13% (n=1) | 12 | 1 | 0% | 0% | |
|
| ||||||
| 11.0 Gy | Control (n=22) | 32% | 16.1 ± 2.8 | 2.1 ± 0.5 | 57% | 0% |
|
| ||||||
| Neupogen® on day 1 (n=5) | 0% | NA | NA | NA | NA | |
|
| ||||||
| Neupogen® on day 3 (n=8) | 25% | 8.0 ± 1.0 | 1.5 ± 0.5 | 50% | 0% | |
|
| ||||||
| Neupogen® on day 5 (n=8) | 0% | NA | NA | NA | NA | |
Rhesus macaques were exposed to 10.0 or 11.0 Gy PBI/BM5 utilizing 6 MV LINAC-derived photons. Animals were administered control article (5% dextrose in water) or Neupogen® beginning at the indicated times post-irradiation, through the third consecutive day an ANC ≥ 1,000 cells μL−1 was observed post-nadir. FN was defined as ANC < 500 cells μL−1 with rectal body temperature ≥ 103.0 °F (39.4 °C), and blood cultures were collected on days when FN was observed. The time values displayed are means ± sem.