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. 2022 Sep 5;11:51. doi: 10.1186/s40164-022-00302-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — The characteristics of circRIC8B. A The annotated region in RIC8B gene for the formation of circRIC8B was shown. The exact sequence of the back splicing site in circRIC8B was confirmed by sequencing. B qRT–PCR for the abundance of circRIC8B and RIC8B mRNA in CLL cells treated with RNase R. Data are shown as means ± SD (n = 3, ^***P < 0.001). C qRT–PCR for the abundance of circRIC8B and RIC8B mRNA in CLL cells treated with actinomycin D at the indicated time points. Data are shown as means ± SD (n = 3, ^**P < 0.01, ^***P < 0.0001). D Nuclear and cytoplasmic fraction assay for the determination of the location of circRIC8B and RIC8B in CLL cells. U6 were applied as positive controls. E RNA-FISH for circRIC8B. circRIC8B was stained with cy3 labeled probe. Nuclei were stained with DAPI. Scale bar, 10 μm. Data are shown as means ± SD (n = 3, ^**P < 0.01, ^***P < 0.001)