Table 2.

CCD matrix and corresponding response values

Run order	Point type	A	B	C	D	Arabitol (g/L)	Yield (g/g)
1	Factorial	+ 1	− 1	− 1	+ 1	3.4	0.070
2	Axial	0	+ α	0	0	20.1	0.253
3	Axial	− α	0	0	0	1.8	0.077
4	Center	0	0	0	0	16.2	0.220
5	Axial	0	0	0	− α	15.6	0.196
6	Factorial	+ 1	+ 1	− 1	+ 1	18.9	0.204
7	Factorial	− 1	− 1	+ 1	+ 1	6.6	0.134
8	Axial	0	-α	0	0	4.5	0.079
9	Center	0	0	0	0	17.4	0.212
10	Factorial	− 1	+ 1	− 1	− 1	7.3	0.147
11	Axial	0	0	− α	0	19.2	0.250
12	Factorial	− 1	+ 1	+ 1	− 1	12.4	0.244
13	Center	0	0	0	0	19.0	0.236
14	Factorial	+ 1	+ 1	+ 1	− 1	24.0	0.293
15	Factorial	+ 1	− 1	+ 1	− 1	10.2	0.177
16	Factorial	+ 1	− 1	+ 1	+ 1	14.7	0.251
17	Axial	0	0	+ α	0	20.4	0.246
18	Factorial	− 1	− 1	− 1	− 1	6.4	0.137
19	Factorial	− 1	+ 1	+ 1	+ 1	11.7	0.205
20	Center	0	0	0	0	19.0	0.228
21	Factorial	+ 1	+ 1	− 1	− 1	21.0	0.199
22	Factorial	− 1	− 1	− 1	+ 1	5.9	0.121
23	Axial	+ α	0	0	0	8.6	0.189
24	Factorial	+ 1	− 1	− 1	− 1	1.9	0.068
25	Center	0	0	0	0	16.0	0.221
26	Factorial	− 1	− 1	+ 1	− 1	12.0	0.253
27	Axial	0	0	0	+ α	20.0	0.230
28	Factorial	+ 1	− 1	+ 1	+ 1	28.0	0.291
29	Factorial	− 1	+ 1	− 1	+ 1	6.6	0.140
30	Center	0	0	0	0	18.3	0.240

Response values are those registered at the time point when glycerol was depleted or, at the latest, after 140 h of fermentation.