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. 2015 Oct 19;77(3):278–284. doi: 10.1590/S1808-86942011000300002

Figure 1.

Figure 1

HE stained histological sections of the mucosal lining epithelium of the border of the tongue in experimental animals. (a) and (b) Negative control groups (CTR1 and CTR2) showing a normal epithelium. (c) Group TUM1 showing a hyperkeratinized epithelium (HQ) with dysplasia; note the droplet-shaped entrapped papillae (pg). (d) Group TUM1 showing moderate cell pleomorphism and hyperchromatic vell nuclei, evident basilar hyperplasia (hp) and basal mitosis (light arrow) and suprabasal mitosis (dark arrows). (e) Group TUM2 showing epithelium with dysplasia extending to the middle third, similar to TUM1. (f) Group PROP1 showing nuclear hyperchromatism in epithelial cells, highlighting droplet-shaped irregular papillae (Frame). (g) Group PROP2 showing rare and focal atypical findings expressed as discreet droplet-shaped papillae (pg) and mild nuclear hyperchromatism. (h) Group PROP3 showing only mildly disarrayed architecture of epithelial papillae and mildly hyperchromatic cell nuclei.