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. 2022 Aug 22;15:982316. doi: 10.3389/fnmol.2022.982316

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Copyright © 2022 Rapedius, Obergrussberger, Humphries, Scholz, Rinke-Weiss, Goetze, Brinkwirth, Rotordam, Strassmaier, Randolph, Friis, Liutkute, Seibertz, Voigt and Fertig.

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Pharmacology of Na_V1.5 recorded in standard and fluoride-free internal solution. (A) Raw current traces from an example CHO cell expressing Na_V1.5 recorded in standard internal solution were blocked by tetracaine using a 3-step protocol (voltage protocol shown at the top). Traces elicited by the first (holding potential –120 mV) and second (holding potential –100 mV) step are shown. (B) Raw current traces from an example CHO cell expressing Na_V1.5 recorded in fluoride-free internal solution were blocked by tetracaine. (C) Corresponding time course of block by tetracaine in standard internal solution for an average of 23 wells (at different holding potentials), time course in DMSO for an average of 41 wells is also shown. (D) Corresponding time course of block by tetracaine in fluoride-free internal solution for an average of 10 wells (at different holding potentials), time course in DMSO for an average of 35 wells is also shown. (E) Concentration response curves for tetracaine in standard internal solution or fluoride-free solution at a holding potential of –120 mV are shown overlaid. (F) Concentration response curves for tetracaine in standard internal solution or fluoride-free solution at a holding potential of –100 mV are shown overlaid.