Table 2.
Defining organ/system failure using the CLIF Consortium Organ Failure Score (CLIF-OF) [14]
| Organ system | Parameter | Score=1 | Score=2 | Score=3 |
|---|---|---|---|---|
| Liver | Serum bilirubin (mg/dL) | <6 | 6≤12 | >12 |
| Kidney | Serum creatinine (mg/dL) | <2 | 2<3.5 | ≥3.5 or renal replacement therapy |
| Brain | West-Haven Grade | 0 | I-II | III-IV |
| Coagulation | INR | <2.0 | 2.0<2.5 | ≥2.5 |
| Circulation | MAP (mmHg) | ≥70 | <70 | Vasopressors |
| Respiratory | PaO2/FiO2 | >300 | ≤300 and >200 | ≤200 |
| OR SpO2/FiO2 | >357 | >214 and ≤357 | ≤214 |
mg/dL milligrammes per deciliter, INR International Normalized Ratio, MAP Mean arterial pressure, mmHg millimetres of mercury, PaO2 Partial pressure of arterial oxygen, FiO2 Fraction of inspired oxygen, SpO2 pulse oximetric saturation